ea0026p186 | Neuroendocrinology | ECE2011
Liu J
, Bisschop P
, Eggels L
, Foppen E
, Zhou J N
, Fliers E
, Kalsbeek A
Background: Previous studies reported that direct injection of estrogen (E2) into different hypothalamic nuclei affects food intake, body weight and locomotor activity. We hypothesized that E2 signaling in the hypothalamus regulates glucose metabolism independently of circulating estrogen levels.Methods: We investigated the effects of hypothalamic estrogen administration on basal glucose production as well as on hepatic and peripher...